03. CJC-1295
(Tetrasubstituted 30-Amino Acid Peptide Hormone)

CJC-1295 – (Tetrasubstituted 30-Amino Acid Peptide Hormone)

CJC-1295 is a synthetic analogue of GHRH (growth hormone releasing hormone) consisting of 30 amino acids. It effectively increases growth hormone secretion and IGF-1 levels without affecting GH pulsatility.

To enhance its specificity as a GHRH, CJC-1295 is often combined with Ipamorelin. This combination promotes growth hormone secretion without stimulating appetite or increasing cortisol, acetylcholine, prolactin, and aldosterone levels. It is well-tolerated and works well when used with Ipamorelin.

Gland Stimulated: Pituitary

Benefits of CJC-1295 :

– Increased growth hormone secretion and IGF-1 levels without raising prolactin
– Enhanced body weight and length through increased protein synthesis
– Improved muscle growth
– Increased bone density
– Enhanced immune function
– Improved cognition and memory
– Increased collagen production
– Fat loss
– Enhanced cellular repair and regeneration

CJC-1295 also promotes deep sleep, which is crucial for muscle growth, memory retention, and rejuvenation.

Two types of CJC-1295 :

1. GHRH: Produced in the hypothalamus, it triggers pulsatile release of GH from the pituitary gland. GHRH has a short half-life of a few minutes.
2. Modified CJC-1295: The first 29 amino acids of GHRH are the active segment. Sermorelin, a manufactured peptide, contains these amino acids. CJC-1295 was developed to increase the half-life to 30 minutes. CJC-1295 + DAC (Drug Affinity Complex) further extends the half-life to 8 days. There is also a non-DAC form that mimics a natural GH spike each night.

The longer half-life of CJC-1295 + DAC means injections are needed once or twice a week. However, this constant blood level may decrease the GH pulse amplitude, resulting in reduced GH tissue stimulation.

Safety :

When using long-acting CJC molecules, it is recommended to take “hormone holidays” of three months every three to six months to allow the pituitary to recover. Sermorelin is used instead of CJC-1295 + DAC during these breaks.

“Hormone holidays” can also reduce the risk of GH resistance. This resistance may occur due to antibodies binding to and inactivating GH or a decrease in the number of GH receptors on tissues. However, these concerns are theoretical, as no long-term studies have been conducted to confirm them.

Side effects of CJC-1295 may include injection site reactions, headache, diarrhea, vasodilation, nausea, and abdominal pain.